Interferon-γ polymorphisms in systemic lupus erythematosus
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چکیده
منابع مشابه
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The pleiotropic cytokine interferon alpha is involved in multiple aspects of lupus etiology and pathogenesis. Interferon alpha is important under normal circumstances for antiviral responses and immune activation. However, heightened levels of serum interferon alpha and expression of interferon response genes are common in lupus patients. Lupus-associated autoantibodies can drive the production...
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متن کاملp21 gene polymorphisms in systemic lupus erythematosus.
OBJECTIVE Cyclin-dependent kinase inhibitor 1A (p21) is a negative regulator in the cell cycle. Development of sex-linked lupus-like syndrome in p21-/- mice and reduced p21 gene expression in patients with systemic lupus erythematosus (SLE) compared with those in healthy controls suggested that p21 is a susceptibility gene of SLE. We investigated the same by a case-control association study. ...
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BACKGROUND & OBJECTIVES Receptors for the Fc fragment of immunoglobulin G (Fc γ Rs) represent the link between humoral and cellular immune responses. Polymorphisms in Fc γ Rs have been identified as genetic factors influencing susceptibility to various autoimmune diseases. This study was aimed to identify Fc γ R IIB genotypes in Indian systemic lupus erythematosus (SLE) patients and to correlat...
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2001
ISSN: 1466-4879,1476-5470
DOI: 10.1038/sj.gene.6363775